研究兴趣：

1. 研究动物在学习和记忆过程中AMPA受体的行为和贡献，阐明神经突触可塑性及多种动物行为的生理机制。
2. 研究AMPA受体突触可塑性异常在神经精神疾病（抑郁障碍、阿尔茨海默病）发病过程中的病理作用，探索早期诊断和及时干预疾病的新策略和途径。

代表性科研论文：

1. Zhou R, Li J, Chen Z, Wang R, Shen Y, Zhang R, Zhou F*, Zhang Y*. (2023). Pathological hemodynamic changes and leukocyte transmigration disrupt the blood–spinal cord barrier after spinal cord injury. J Neuroinflammation. 20(1):118.

2. Liu Z#, Ma H#, Long S, Zhang Y*. (2022). Metabotropic Glutamate Receptor 5: a Potential Molecular Switch and Beyond. Biol Psychiatry. 92:98-99.  

3. Ma H, Li CY, Wang JP, Zhang XC, Li MY, Zhang R, Huang Z, Zhang Y*. (2021). Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors. Proc Natl Acad Sci U S A. 118(6): e2019409118.

4. Chen J#, Zhang XC#, Li LP#, Ma XQ, Yang CX, Liu ZD, Li CY, Fernandez-Cabezudo M, al-Ramadi BK, Wu C, Huang WS, Zhang Y*, Zhang YH*, Liu WL*. (2021). Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLOS Biol. 19(4): e3001134.

5. Roth RH, Cudmore R, Tan H, Hong I, Zhang Y, Huganir RL*. (2020). Cortical Synaptic AMPA Receptor Plasticity During Motor Learning. Neuron. 105: 895-908.

6. Mehta S#*, Zhang Y#, Roth RH#, Zhang JF, Mo A, Tenner B, Huganir RL*, Zhang J*. (2018). A Suite of Single-fluorophore Biosensors for Sensitive and Multiplexed Detection of Signaling Activities. Nat Cell Biol. 20:1215-1225.

7. Roth RH#, Zhang Y#, Huganir RL*. (2017). Dynamic imaging of AMPA receptor trafficking in vitro and in vivo. Curr Opin Neurobiol. 45: 51-58.

8. Zhang Y#, Cudmore R#, Lin DT, Linden DJ, and Huganir RL*. (2015). Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo. Nat Neurosci. 18: 402-407.

9. Sharma K, Choi SY, Zhang Y, Nieland T, Long S, Li M, and Huganir RL*. (2013). High-throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development. Cell Rep. 5: 1330-1341.

10. Zhang Y#, Gao X#, Saucedo L, Ru B, Edgar B, and Pan D*. (2003). Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol. 5: 578-581.

11. Gao X#, Zhang Y#, Arrazola P, Hino O, Kobayashi T, Yeung R, Ru B, and Pan D*. (2002). Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling. Nat Cell Biol. 4: 699-704.

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