Research Interests:
With a focus on growth factor receptor signalling, the aim of our research is the discovery of novel biological principles and mechanisms of general importance for nervous system development and metabolic regulation.
Selected Publications:
We do not yet have publications from the Beijing laboratories, as these are just being established. Please see our recent publications from our lab at the Karolinska Institute HERE and from the NUS lab in Singapore HERE.
1. Yi, C., Goh, K. Y., Wong, L. W., Ramanujan, A., Tanaka, K., Sajikumar, S., & Ibanez, C. F. (2021).Inactive variants of death receptor p75(NTR) reduce Alzheimer's neuropathology by interfering with APP internalization. EMBO J, 40(2), e104450. doi:10.15252/embj.2020104450
2. Gongrich, C., Krapacher, F. A., Munguba, H., Fernandez-Suarez, D., Andersson, A., Hjerling-Leffler, J., & Ibanez, C. F. (2020). ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons. J Cell Biol, 219(1). doi:10.1083/jcb.201905002
3. Marmol, P., Krapacher, F., & Ibanez, C. F. (2020). Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7. Elife, 9. doi:10.7554/eLife.54721
4. Guo, T., Marmol, P., Moliner, A., Bjornholm, M., Zhang, C., Shokat, K. M., & Ibanez, C. F. (2014). Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife, 3, e03245. doi:10.7554/eLife.03245
5. Vilar, M., Charalampopoulos, I., Kenchappa, R. S., Simi, A., Karaca, E., Reversi, A., . . . Ibanez, C. F. (2009). Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron, 62(1), 72-83. doi:10.1016/j.neuron.2009.02.020
6. Bertolino, P., Holmberg, R., Reissmann, E., Andersson, O., Berggren, P. O., & Ibanez, C. F. (2008). Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc Natl Acad Sci U S A, 105(20), 7246-7251. doi:10.1073/pnas.0801285105
7. Ledda, F., Paratcha, G., Sandoval-Guzman, T., & Ibanez, C. F. (2007). GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat Neurosci, 10(3), 293-300. doi:10.1038/nn1855
8. Vilar, M., Murillo-Carretero, M., Mira, H., Magnusson, K., Besset, V., & Ibanez, C. F. (2006). Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J, 25(6), 1219-1230. doi:10.1038/sj.emboj.7601017
9. Pozas, E., & Ibanez, C. F. (2005). GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron, 45(5), 701-713. doi:10.1016/j.neuron.2005.01.043
10. Paratcha, G., Ledda, F., & Ibanez, C. F. (2003). The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell, 113(7), 867-879. doi:10.1016/s0092- 8674(03)00435-5
11. Ledda, F., Paratcha, G., & Ibanez, C. F. (2002). Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5. Neuron, 36(3), 387- 401. doi:10.1016/s0896-6273(02)01002-4
Lab Website:
http://carlosibanezlab.se/PKU/