Principal Investigator

岳伟华
精神疾病的遗传易感性研究

联系电话：
通信地址： 北京市海淀区花园北路51号, 北京大学第六医院(精神卫生研究所)；邮编 100191
电子邮件：[email protected]

　　

研究兴趣：

主要从事常见精神障碍(精神分裂症、抑郁障碍、孤独谱系障碍、双相障碍等)的遗传易感性研究，包括对发病风险和药物疗效基因的精细定位及功能注释、多组学验证分析，为阐明精神分裂症的发病机制和优化个体化治疗方案提供科学依据。主要发现：1)采用基因组学研究策略，发现并验证中国汉族人群常见精神障碍的新型易感基因并解析其部分生物功能；2)利用多组学技术揭示遗传变异影响常见精神障碍患者基因转录、表观遗传及脑影像学特征，探索遗传环境交互作用对认知和情绪的影响；3)在基因组水平发现抗精神病药疗效个体差异新型靶基因和差异甲基化位点，多基因和多甲基化风险值疗效模型的预测效果良好，为阐释精神障碍发病机制和指导合理用药提供了新思路，实现精神科精准医疗的临床转化应用。

　

代表性科研论文：

  1. Guo L, Su Y, Zhang Y, Yu H, Lu Z, Li W, Yang Y, Xiao X, Yan H, Lu T, Li J, Liao Y, Kang Z, Wang L, Li Y, Li M, Liu B, Huang H, Lv L, Yao Y, Tan Y, Breen G, Everall I, Wang H, Huang Z*, Zhang D*, Yue W*. (2023) Prediction of treatment response to antipsychotic drugs for precision medicine of schizophrenia: randomized trials and multi-omics analysis. Mil Med Res. 10(1):24.
  2. Hu S#, Li H#, Yu H#, Liu Y#, Liu C, Zuo X, Lu J, Xi C, Huang B, Jiang J, Xu H, Hu J, Lai J, Huang M, Liu J, Xu D,  Guo X, Wu W, Wu X, Jiang J, Li M, Zhang G, Huang J, Wei N, Lv W, Duan J, Qi H, Hu C, Chen J, Zhou W, Xu W, Liu C, Liang H, Du J, Zheng S, Lu Q, Zheng L, Hu X, Chen F, Chen P, Zhu B, Xu L, Ni Z, Fang Y, Yang Z, Shan X, Zheng E, Zhang F, Zhou Q, Rao Y, Swaab D, Yue W*, Xu Y*. (2021) Discovery of new genetic locus for male sexual orientation in Han population. Cell Discov. 7(1):103.
  3. Lam M#, Chen C#, Li Z, Martin A, Bryois J, Ma X, Gaspar H, Ikeda M, Benyamin B, Brown B, Liu R, Zhou W, Guan L, Kamatani Y, Kim S, Kubo M, Kusumawardhani A, Liu C, Ma H, Periyasamy S, Takahashi A, Wang Q, Xu Z, Yu H, Zhu F, Psychiatric Genomics Consortium - Schizophrenia Working Group†, Indonesia Schizophrenia Consortium, Genetic, REsearch on schizophrenia neTwork-China and Netherland (GREAT-CN), Chen W, Faraone S, Glatt S, He L, Hyman S, Hwu H, Li T, McCarroll S, Neale B, Sklar P, Wildenauer D, Yu X, Zhang D, Mowry B, Lee J, Holmans P, Xu S, Sullivan P, Ripke S, O’Donovan M, Daly M, Qin S, Sham P, Iwata N, Hong K, Schwab S, Yue W*, Tsuang M*, Liu J*, Ma X*, Kahn R*, Shi Y*, Huang H*. (2019) Comparative genetic architectures of schizophrenia in East Asian and European populations. Nat Genet. 51(12): 1670-1678.
  4. Lu Z, Zhang Y, Sun Y, Liao Y, Kang Z, Feng X, Yan H, Li J, Wang L, Lu T, Zhang D, Yue W*. (2023) Therapeutic outcomes wide association scan (TOWAS) of different antipsychotics in schizophrenia. Psychiatry Clin Neurosci. May 21. doi: 10.1111/pcn.13567. Online ahead of print.
  5. Lu Z#, Zhang Y#, Sun Y, Liao Y, Kang Z, Feng X, Yan H, Li J, Wang L, Lu T, Zhang D, Huang Y*, Yue W*. (2023) The positive association between antipsychotic-induced weight gain and therapeutic response: new biotypes of schizophrenia. Psychiatry Res. 324:115226.
  6. Lv H#, Li J#, Gao K, Zeng L, Xue R, Liu X, Zhou C, Yue W*, Yu H*. (2022) Identification of genetic loci that overlap between schizophrenia and metabolic syndrome. Psychiatry Res. 318: 114947.
  7. Dong L#, Yan H#, Huang X#, Hu X, Yang Y, Ma C, Du B, Lu T, Jin C, Wang L, Yu H, Dong Z, Li W, Ruan Y, Zhang H, Zhang H, Mi W, Ma W, Li K, Lv L, Zhang D, Yue W*. (2015) A2BP1 gene polymorphisms association with olanzapine-induced weight gain. Pharmacol Res 99: 155-161.
  8. Yu H, Yan H, Wang L, Li J, Tan L, Deng W, Chen Q, Yang G, Zhang F, Lu T, Yang J, Li K, Lv L, Tan Q, Zhang H, Xiao X, Li M, Ma X, Yang F, Li L, Wang C, Li T, Zhang D, Yue W*, Chinese Antipsychotics Pharmacogenomics Consortium. (2018) Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. Lancet Psychiatry 5(4):327-338.
  9. Yu H, Liu C, Li Z, Zhang X, Cai L, Wang Q, Iwata N, Ikeda M, Yan H, Wang L, Lu T, Chinese Schizophrenia Genetics Group, Li T, Liu B, Shi Y, Zhang D, Yue W*. (2017) Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Chinese Han population. Mol Psychiatry 22(7):954-960.
  10.  Yue WH#, Wang HF, Sun LD#, Tang FL, Liu ZH, Zhang HX, Li WQ, Zhang YL, Zhang Y, Ma CC, Du B, Wang LF, Ren YQ, Yang YF, Hu XF, Wang Y, Deng W, Tan LW, Tan YL, Chen Q, Xu GM, Yang GG, Zuo XB, Yan H, Ruan YY, Lu TL, Han X, Ma XH, Wang Y, Cai LW, Jin C, Zhang HY, Yan J, Mi WF, Yin XY, Ma WB, Liu Q, Kang L, Sun W, Pan CY, Shuang M, Yang FD, Wang CY, Yang JL, Li KQ, Ma X, Li LJ, Yu X, Li QZ, Huang X, Lv LX, Li T, Zhao GP, Huang W*, Zhang XJ, Zhang D*. (2011) Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet 43(12): 1228-1231.