题目：Age-related Changes in the Neural Stem Cell Niche

报告人：Sally Temple, Ph.D Scientific Director Neural Stem Cell Institute, USA

时间：2014年10月21日 星期二 16:00-

地点： Room143, New Biology Building, THU

邀请人: Dr. Qin Shen

摘要: Neural stem cells (NSCs) exist in specialized sites in the mature mammalian nervous system, producing neurons and glia throughout life. The mouse subventricular zone (SVZ) is a beautiful model system for studying how the environment regulates stem and progenitor cell behavior in an adult niche.  Dr. Temple’s group has identified several factors that control the behavior of SVZ NSCs, including VCAM1 and SDF1, factors that also play key roles in blood stem cell homing and adhesion in the bone marrow niche. This conservation between brain and blood implies that there may be fundamental rules for activating and recruiting stem cells across lineages, and an understanding of this process could be used to harness cells with regenerative potential in a variety of organ systems. Recently, Dr. Temple’s team has defined changes in NSCs and their niche that accompany the aging process, and they are actively seeking ways to rejuvenate the system, to better maintain this important system.