题目：Molecular Mechanisms of Dendrite Morphogenesis

报告人：沈康教授

Dr. Kang Shen got his bachelor’s degree of medicine from Tongji Medical University in China. Instead of becoming a doctor, he traveled to Duke University to study for a Ph.D in cell biology and neuroscience. After grad school, he moved to UCSF and began a postdoctoral fellowship in the lab of HHMI investigator Cornelia Bargmann, where he studied the development of nervous system on C. elegans. Dr. Shen set up his own lab at Stanford University from 2003 and focused on studying how neurons build synaptic connections. His lab has found some positive signals that encourage synapse formation and some negative signals that ward off neurons trying to establish an inappropriate connection.

时间：2015年09月22日 星期二 13:00-14:30

地点： 北京大学王克桢楼1113室

The complex and diverse dendritic arbors have long been recognized as a critical feature of distinct neuronal cell types. The molecular knowledge on dendrite development and cell biology is critical for our understanding of neural circuit assembly and function. Using the highly branched sensory neurons in C. elegans, I will present our recent work on the molecular mechanisms of dendrite growth and branching. We have identified extracellular guidance cues, dendritic receptors and intracellular machineries that guide the growth of the dendrites.  I will discuss the dynamic regulation of cell surface receptors as a potential mechanism to provide flexible guidance choices during the development of the nervous system.