题目：How to send a protein to axon or dendrite?

报告人：Prof. Kang Shen

报告人简介：

Dr. Kang Shen got his bachelor’s degree of medicine from Tongji Medical University in China. Instead of becoming a doctor, he traveled to Duke University to study for a Ph.D in cell biology and neuroscience. After grad school, he moved to UCSF and began a postdoctoral fellowship in the lab of HHMI investigator Cornelia Bargmann, where he studied the development of nervous system on C. elegans. Dr. Shen set up his own lab at Stanford University from 2003. His lab use C. elegans as a model system to study the molecular mechanisms of synapse formation, synaptic target recognition and axonal transport.

时间：2015年09月26日 星期六 8:30-9:30

地点： 金光生命科学大楼 邓祐才报告厅101

邀请人：李毓龙

摘要：

The cardinal feature of neuronal polarization is the establishment and maintenance of axons and dendrites. How axonal and dendritic proteins are sorted and targeted to different compartments is poorly understood. Here, we identified distinct di-leucine motifs that are necessary and sufficient to target transmembrane proteins to either the axon or the dendrite through direct interactions with the clathrin-associated adaptor protein complexes (APs) in C. elegans. Axonal targeting requires AP-3, while dendritic targeting is mediated by AP-1. The axonal di-leucine motif binds to AP-3 with higher affinity than to AP-1. Both AP-3 and AP-1 are localized at the Golgi and endosomes in the soma. We propose that AP-3 and AP-1 directly select transmembrane proteins and target them to axon and dendrite, respectively, by sorting them into distinct vesicle pools.