题目：Clinical, genetic, and biochemical characterization of human circadian regulation

报告人：Prof. Louis J. Ptá?ek, MD

时间：2017年11月06日 星期一 13:00-15:00

地点： 北京大学王克桢楼1113会议室

Sleep regulation is a very mysterious phenomenon. Despite the fact that sleep is an essential component of the human experience occupying ~1/3 of our lives, little is known about what sleep is and what purposes it serves. It is clear that chronic disruption of sleep leads to increased risks of not only motor vehicle accidents, but also many diseases like cancer, obesity and diabetes, autoimmune disorders, neurodegeneration, and psychiatric diseases. We’ve reported genes and mutations that cause people to be extreme morning larks (lifelong tendency to go to sleep and to wake up very early). We and our collaborators have also reported the first families and gene/mutation causing people to be natural short sleepers, with a life-long requirement of only 4-6 hours of sleep/night to feel good and perform at a high level. We’ve used human genetics in combination with detailed biochemical analysis and circadian phosphoproteomics to help reveal basic mechanistic insights underlying the mysteries of human sleep behavior. Our vision for this work is to ultimately improve human safety and health. Insights into the details of sleep mechanisms will ultimately lead to better sleep medicines for travelers and shift workers. In addition to decreasing disease risks, such medications will also be used in conjunction with other medications to align drug administration with the best circadian time-of-day to optimize the benefit while minimizing side-effects.

邀请人：饶毅 教授