Title: Molecular Mechanisms of AMPA Receptor Trafficking

Speaker: Victor Anggono, Ph.D.，The University of Queensland

Time: October 25 2017 (Wed) 13:00-15:00

Venue: Room 1113 Wang Kezhen Building

The AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in mammalian central nervous system. Dynamic changes in synaptic strength, known as synaptic plasticity, are thought to underlie information coding and storage during learning and memory. Aberrant trafficking of AMPARs into and out of synapses usually leads to impairment in synaptic plasticity and deficits in learning and memory. More importantly, evidence in the literature has shown that defective glutamatergic neurotransmission contributes to cognitive decline associated with many neurodegenerative diseases and neuropsychiatric disorders. Here, I will discuss our efforts in understanding the molecular mechanisms underlying the regulation of AMPAR trafficking by AMPAR interacting proteins as well as by post-translational modifications that occur on their carboxy-termini. I will highlight our recent work on the regulation of AMPAR intracellular trafficking by post-translational ubiquitination and its involvement in the amyloid-beta-induced synaptic depression. In addition, I will also present our new finding describing the role of a novel calcium-binding protein in regulating the expression and trafficking of AMPARs in mammalian central neurons.

Host PI：Dr.Yong Zhang